dietary supplementin the free acid form,-hydroxy-methylbutyric acid (HMB-FA), and as a‚monohydrated calcium salt of the conjugate base, calcium -hydroxy -methylbutyrate monohydrate (HMB-Ca, CaHMB) Since only a small fraction of HMB's metabolic precursor,‚l-leucine, is metabolized into HMB, pharmacologically active concentrations of the compound in‚blood plasma‚and muscle can only be achieved by supplementing HMB directly.[1][30][31]‚A healthy adult produces approximately 0.3‚grams per day, while supplemental HMB is usually taken in doses of‚3“6‚grams per day.[17]‚HMB is sold at a cost of about‚US$30“50‚per month when taken in doses of 3‚grams per day.[16]‚HMB is also contained in several nutritional products and medical foods marketed by‚Abbott Laboratories‚(e.g., certain formulations of‚Ensure,‚Juven, and‚Myoplex),[8][21]‚and is present in insignificant quantities in certain foods, such as‚alfalfa,‚asparagus,‚avocados,‚cauliflower,‚grapefruit, and‚catfish
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